Endocrine Abstracts

Diabetes insipidus (DI) is a syndrome caused by various defects in the secretion or action of the antidiuretic hormone, arginine vasopressin (AVP). They include impaired AVP production (pituitary DI), increased AVP degradation (gestational DI), suppression of AVP secretion by excessive water intake (primary polydipsia) or decreased antidiuretic effect due to various abnormalities in the kidney (nephrogenic DI). In all four types, the severity of the defect varies between patie...